Deoxygenated inositol 1,4,5-trisphosphate analogues and their interaction with metabolic enzymes. (1R,2R,4R)-cyclohexane-1,2,4-tris(methylenesulfonate): a potent selective 5-phosphatase inhibitor

J Med Chem. 1993 Oct 1;36(20):3035-8. doi: 10.1021/jm00072a027.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Calcium Channels / metabolism
  • Cyclohexanes / chemical synthesis*
  • Cyclohexanes / metabolism
  • Cyclohexanes / pharmacology
  • Inositol 1,4,5-Trisphosphate / analogs & derivatives*
  • Inositol 1,4,5-Trisphosphate Receptors
  • Mesylates / chemical synthesis*
  • Mesylates / metabolism
  • Mesylates / pharmacology
  • Molecular Structure
  • Phosphoprotein Phosphatases / antagonists & inhibitors*
  • Receptors, Cytoplasmic and Nuclear / metabolism
  • Structure-Activity Relationship

Substances

  • Calcium Channels
  • Cyclohexanes
  • Inositol 1,4,5-Trisphosphate Receptors
  • Mesylates
  • Receptors, Cytoplasmic and Nuclear
  • cyclohexane-1,2,4-tris(methylenesulfonate)
  • Inositol 1,4,5-Trisphosphate
  • Phosphoprotein Phosphatases